Synergism Between Probiotics And Herbs To Manage Type 2 Diabetes In Rats

Objective: This study aims to explore the adjuvant effect of multi-strain probiotics with either saffron, cardamom, ginger, or cinnamon herbs to achieve synergistic management for controlling type 2 diabetes (T2D). Methods: Eighty-eight adult male, Wistar rats were used. Eight rats were kept as healthy control. Eighty rats were used to induce type 2 diabetic rats (T2DR) and were randomly assigned to ten groups. One group was an offer to 0.2 ml multi-strain probiotics orally. The rest of T2DR were gavage with 100 mg/kg aqueous extract of saffron, cardamom, ginger, or cinnamon without or with 0.2 ml multi-strain probiotics orally. Bodyweight gain (BWG), and feed efficiency ratio (FER) were recorded. Determination of oral glucose tolerance test (OGTT), serum insulin, C-peptide, HDL, LDL, HDL/total cholesterol ratio were performed. Serum antioxidant activity, Th1and Th2 cytokines and histopathology of the pancreas were done. Results: Comparable with T2DR, solely multi-strain probiotics or with herbs caused a significant reduction in BWG (P<0.05). Groups fed saffron, cardamom, and ginger and enriched with multi-strain probiotic showed significant improvement in OGTT, serum insulin, C-peptide and lipid abnormalities (P<0.05) compared to T2DR. Besides, they had antioxidant and anti-inflammatory effects. The group received ginger alone exerted anti-hyperglycemia and anti-inflammatory effects. However, cinnamon had a moderate anti-diabetic effect and solely probiotics did not show a significant benefit for all parameters except BWG. Conclusion: Cardamom, saffron, and ginger enriched with multi-strain probiotics achieve a synergistic relationship for managing T2D. This finding exhibits a possible new hypothesis to manage diabetes that needs further study.

Subconjunctival steroid for pearls like tumour in the anterior chamber of the eye

Pearl like tumor in the anterior chamber of the eye is a not uncommon affection of children eyes, difficult to tract by topical and/or systemic steroid assuming that the condition is allergic in origin. To assess the effect of sub-conjunctival steroid injection in these cases. It is a retrospective study for all patients aged between 10 - 18 years presenting with a unilateral grayish white nodule at the angle of the anterior chamber of the eye sub-conjunctival long acting steroid was given for all patients and the follow up was done for one year. 10 eyes of 10 patients were included in this research. One child was a new case and 9 were recurrent cases. All 10 then had varying degree of anterior ureitis. After steroid injection the severity of iritic decreased in all patients. The size of the lesion decreased to more than 50% after 2 months. sub-conjunctival steroid injection for pearl like lesion in the anterior chamber of the eye is a safe and effective way of treating such lesion

Assessment of neutrophil function in localized pre-pubertal periodontitis

Polymorphonuclear leucocytes [PMNS] from L-PP patients revealed variousdegrees of functional defects. This study was undertaken to investigatechemotaxis, phagocytosis and intracellular killing Poer of PMSs in L-PP agematched controls and adult controls. Peripheral blood PMNs from a total of 6patients with L-PP, 6 age matched pediatric controls, and 5 adult controlswere analyzed for neutrophil function. The results showed that chemotaxis ofPMNs from both L-PP patients and pediatric controls was nearly at the samelevel, but significantly depressed compared to adult controls. There was nosignificant difference between chemotaxis of PMNs from L-PP patients and thatfrom age matched controls. On the other hand, both phagocytosis andintracellular killing power of PMNs from patient with L-PP were matchedcontrols or adult controls. It seems from the results of this study thatneutrophil function in L-PP patients is defective as regard to phagocytosis,intracellular killing but not for chemotaxis